A Sibling-augmented Case-only Approach for Assessing Multiplicative Gene-Environment Interactions
نویسندگان
چکیده
منابع مشابه
A sibling-augmented case-only approach for assessing multiplicative gene-environment interactions.
Family-based designs protect analyses of genetic effects from bias that is due to population stratification. Investigators have assumed that this robustness extends to assessments of gene-environment interaction. Unfortunately, this assumption fails for the common scenario in which the genotyped variant is related to risk through linkage with a causative allele. Bias also plagues other methods ...
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Background: The traditional methods of studying the gene-environment interactions need a control group. However, the selection of an appropriate control group has been associated with problems. Therefore, new methods, such as case-only design, have been created to study such interactions. The objective of this study was to compare the case-only and case-control designs using data from patients ...
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background: the traditional methods of studying the gene-environment interactions need a control group. however, the selection of an appropriate control group has been associated with problems. therefore, new methods, such as case-only design, have been created to study such interactions. the objective of this study was to compare the case-only and case-control designs using data from patients ...
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As one aspect of the complex feature of longevity, gene by sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene by sex interaction are expected. New and valid statistical methods are needed. In this article, we introduce a nontraditional approach, the case-only design, which was originally proposed for ...
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Working papers of the Max Planck Institute for Demographic Research receive only limited review. Views or opinions expressed in working papers are attributable to the authors and do not necessarily reflect those of the Institute. ABSTRACT As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular gen...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2011
ISSN: 1476-6256,0002-9262
DOI: 10.1093/aje/kwr231